Previous studies have found that E3 ubiquitin ligase, including Atrogin-1 and MuRF1, are closely related to skeletal muscle atrophy, and are significantly up-regulated in a variety of skeletal muscle atrophy models (Li et al., 2003; Foletta et al., 2011; Wang et al., 2011). Here, TRIM63 is linked to muscular atrophy.