TRIM63 and muscular atrophy: Furthermore, the overexpression of PGC-1α or activation of the AMPK/PGC-1α signal pathway can inhibit the transcriptional activity of NF-κB, and also decline Atrogin-1 and MuRF1 expression, thereby postponing muscular atrophy (Brault et al., 2010; Kim and Lee, 2017; Liu and Chang, 2018).