In addition, Atrogin-1, MuRF1, and protein ubiquitination show similar changes in various aging tissues (Ziaaldini et al., 2015; Kou et al., 2017), and exercise training can reverse the aging-associated activation of catabolic signaling to fight sarcopenia (Ziaaldini et al., 2015). Here, FBXO32 is linked to sarcopenia.