MAPT and Cognitive impairment: Neuroinflammation (Lee et al., 2008), compromised BBB function (Nelson et al., 2016) and p-tau accumulation (Huber et al., 2017) are inferred to be the main pathological mechanisms underlying cognitive impairment in AD (Zempel and Mandelkow, 2014; van de Haar et al., 2016; Bettcher et al., 2019).