For instance, endothelial cell adhesion molecules PECAM-1 and ICAM-1 (also known as CD31 and CD54, respectively) play a role in regulating interactions between leukocytes and the endothelium and are involved in the AD pathology through their contribution to the inflammatory process within blood vessels (Wennström and Nielsen, 2012). The gene discussed is ICAM1; the disease is Alzheimer disease.