For instance, while pathological processing of amyloid precursor protein (APP) to amyloid β in Alzheimer’s disease has been implicated in disrupting autophagy via the BECN1 complex (Salminen et al., 2013), the normal non-amyloidogenic processing of APP has been associated with neuroprotection in the retina (Cimdins et al., 2019). Here, APP is linked to early-onset autosomal dominant Alzheimer disease.