Concerning subsets of CD4+ T cells, obesity with sepsis resulted in higher percentages of Th2 and Th17 cells at 12, 24, and 48 h and Treg cells at 24 and 48 h, while Th1-expressing cells had decreased by 48 h compared to the obesity sham group. Here, CD4 is linked to obesity due to melanocortin 4 receptor deficiency.