In the first part of our study, we successfully employed Ang II stimulation to establish an in vitro model of liver fibrosis in LX-2 cells, as reflected by increased cell viability, inflammation, ERS, ROS, and ECM-related proteins (α-SMA, Col I, and Col III) in the Ang II-treated LX-2 cells. This evidence concerns the gene AGT and Hepatic fibrosis.