In view of the possible role played by ASK1 in liver fibrogenesis, we performed in vitro experiments designed to elucidate the effects of ASK1 on Ang II-induced HSC proliferation, ECM-related protein expression, ERS, and inflammation to gain a better understanding of the roles played by ASK1 and Ang II in liver fibrosis. Here, AGT is linked to Hepatic fibrosis.