IL6 and infection: Infection by SARS-CoV-2 induces similar complex systemic inflammatory responses releasing proinflammatory cytokines that have numerous pleiotropic effects, including activation of the coagulation cascade which interacts with coagulopathies to form a vicious cycle directly correlated with poor prognosis.33 Ranucci et al28 presented the link between IL-6 levels in COVID-19 patients and ARDS requiring mechanical ventilation.