IL6 and infection: Infection by virus, bacteria, or fungi induces host defense mechanisms, which subsequently increases cellular and humoral immune responses by activation of coagulation cascade and thrombin generation.4 Mucha’s study34 explained cytokine storm as the hallmark of COVID-19 pathophysiology and it is characterized by high levels of inflammatory markers, including IL-1 and IL-6, that promote thrombosis by activating platelets, endothelium, monocytes, and the tissue factor VIIa pathway.