For example, heparinase, an enzyme that degrades heparan sulphate and enhances the invasive and metastatic capacity of cancer cells, was reported to be activated by s-cysteinylation.206 In addition, enzymes involved in the control of oxidative stress can be modulated by s-cysteinylation, as is the case for the metalloenzyme Cu/Zn-superoxide dismutase 1 (SOD1), which catalyses the dismutation of superoxide anions into oxygen and hydrogen peroxide. This evidence concerns the gene SOD1 and cancer.