CBS and ovarian cancer: Similarly, in ovarian cancer cells, CBS inhibition resulted in mitochondrial dysfunction and ROS overproduction (Table 1), consistent with a malfunctioning mETC.58 Mitochondrial bioenergetics are also stimulated by the H2S-generating 3-MST substrate 3-MP (Table 1) both in the murine colon cancer CT26 cell line147 and in mouse hepatoma cells,148 where silencing of 3-MST or SQR decreased basal cellular bioenergetics, further suggesting that mitochondrial bioenergetics are partially sustained by SQR-mediated H2S oxidation (Table 1).