CBS and cancer: Therefore, despite being only a partial effector of carcinogenesis, CBS belongs to a panel of intervening players, including NF-κB, KRAS, p53 and Wnt components, that contribute to metabolic rewiring and increased proliferative and invasive potential.170 Emerging evidence implies a role for CBS in the resistance of cancer cells to ferroptosis,85,171 although the mechanistic details of this observation remain to be unravelled (detailed below).