Most affected were the analyses on AD (strongest reduction in r2 = 73.8% in analyses excluding APOE effects vs. the full model including APOE  in IGAP) and essentially all CSF-Aβ42 related measures (strongest reduction in r2 = 88.9% for trait “AB_Zscore” in IGAP) for both PRS models. Here, APOE is linked to Alzheimer disease.