Comparing AD vs. controls showed the expected strong signals in the APOE region on chromosome 19q reaching genome-wide suggestive significance in the SNP-based analyses (best SNP rs429358: OR = 2.26, 95% CI = 1.66–3.07, P = 2.68E-07; Supplementary Fig. 1 and Supplementary Table 2) and genome-wide significant association in the gene-based tests (APOC1 [P = 3.24E-07] and APOE [P = 3.39E-07]; Supplementary Fig. 1B and Supplementary Table 2). Here, APOE is linked to Alzheimer disease.