In tumor tissues, the relative mRNA expression levels of hsa_circ_0002286, hsa_circ_0000512 and TRIM2 were lower than those in normal tissues (P < 0.01), while the expression levels of hsa-mir-222-5p was significantly increased in tumor tissues (P < 0.01) (Figure 11A). This evidence concerns the gene TRIM2 and neoplasm.