Of note, PVT1, which contained a genomic region indicative of high cancer risk [53, 54], was conjectured to involve in ozone-caused asthma progression, allowing for that PVT1 expression was strongly correlated with ASMC function and Th1/Th2 balance of ozone-treated asthma mice models (Figures 2, 3). The gene discussed is PVT1; the disease is cancer.