In our previous circRNA microarray study, we found a series of aberrantly expressed circRNAs in HCC [17], including circ-LRIG3 (hsa_circ_0027345, chr12: 59277301–59,308,117), a circRNA derived from the back-splicing of LRIG3 exon 2 ~ 11. Here, LRIG3 is linked to hepatocellular carcinoma.