In a meta-analysis of 27 studies, including approximately 7300 patients, treatment with SGLT2 inhibitors in people with T2D and CKD was not associated with increased risks of adverse renal events (HR: 1.04; 95% CI 0.68, 1.61), AKI (HR: 0.69; 95% CI 0.45, 1.06), or hyperkalemia (HR: 0.63; 95% CI 0.48, 0.83), compared with controls [45]. This evidence concerns the gene SLC5A2 and acute kidney injury.