SLC5A2 and kidney disorder: Furthermore, the positive effect seen with GLP-1 RAs seemed to be largely confined to progression to macroalbuminuria, while SGLT2 inhibitors reduced the risk of worsening eGFR, ESKD, or death from kidney disease (HR: 0.55; 95% CI 0.48, 0.64); GLP-1 RAs had no significant effect on this particular composite (HR: 0.92; 95% CI 0.80, 1.06) [132].