SLC5A2 and type 2 diabetes mellitus: The renoprotective effects of SGLT2 inhibitors in people with T2D have been evaluated in five major CV outcomes trials (CVOTs): EMPA-REG OUTCOME (empagliflozin) [24], CANVAS program, which comprised two randomized, double-blind, placebo-controlled phase 3 trials: CANVAS and CANVAS-R (canagliflozin) [22], DECLARE-TIMI 58 (dapagliflozin) [23], and VERTIS CV (ertugliflozin) [32].