CHI3L1 and Alzheimer disease: In our previous study, we found that the 2-({3-[2-(1-cyclohexene-1-yl)ethyl]-6,7-dimethoxy-4-oxo-3,4-dihydro-2-quinazolinyl}sulfanyl)-N-(4-ethylphenyl)butanamide (K284-6111) alleviated memory dysfunction and neuroinflammation by inhibiting CHI3L1 in Αβ infusion AD mouse model [34].