The same collaboration found that sFlt-1:PlGF and a ratio of combining four metabolites (1-(1-enyl-stearoyl)-2-oleoyl-GPC, 1,5-anhydroglucitol,5α-androstan-3α,17α-diol disulfate and N1,N12-diacetylspermine) is a better predictor of fetal growth restriction than sFlt-1:PlGF combined with risk factors [31]. The gene discussed is PGF; the disease is fetal growth restriction.