Two major CCN3 isoforms were detected in plasma of both MS patients and healthy controls at approximately 54 kDa and 25 kDa, likely representing full-length CCN3 and the amino-truncated isoform detected in the control cell culture-conditioned medium of h295-R cells expressing CCN3 [43] (Fig. 1e). Here, CCN3 is linked to myeloid sarcoma.