Goats that had been vaccinated and then depleted of 99.9% of their CD8+ T cells before challenge showed no sign of viraemia, no pyrexia and no major clinical signs, apart from a very mild and transient diarrhoea in three out of five animals, which may point to a particular role of previously primed CD8+ T cells in clearing PPRV from the gut mucosa in vaccinated animals, although it could also be examples of the transient clinical signs we have previously seen in vaccinated goats challenged with wild‐type PPRV (Hodgson et al., 2018). This evidence concerns the gene CD8A and Fever.