Compared with non-diabetes, the proliferating angiogenesis factors such as HGF secreted by CD34+ cells of diabetes are reduced, while the secretion of proinflammatory and profibrotic factors such as TGF-β1 is increased, and meanwhile, the proliferation and migration ability of EPCs which can be responded by stromal-derived factor-1 is reduced114. The gene discussed is HGF; the disease is diabetes mellitus.