The results showed that 15 hub genes, including CCNB1, KIF23, KIF4A, ZWINT, CENPE, KIF15, MCM3, NEK2, BUB1B, EZH2, MCM2, MIKI67, CHEK1, KIF14, and PCLAF were significantly upregulated in tumor tissues (Supplementary Figure 5). Here, NEK2 is linked to neoplasm.