Kaplan-Meier survival curve analysis showed that low expression of NOS1, ALAD, ACADM, SCD5, and CA4 genes and high expression of ALDH3B2, ITPKA, IMPDH1, FADS2, ACHE, and HK3 genes was associated with shorter overall survival of ccRCC patients. The gene discussed is FADS2; the disease is nonpapillary renal cell carcinoma.