Multivariate Cox regression analysis showed that 11 of the 12 genes, namely, NOS1, ALAD, ALDH3B2, ACADM, ITPKA, IMPDH1, SCD5, FADS2, ACHE, CA4, and HK3 independently predicted prognosis of ccRCC patients. The gene discussed is CA4; the disease is nonpapillary renal cell carcinoma.