Multivariate Cox regression analysis showed that 11 of the 12 genes, namely, NOS1, ALAD, ALDH3B2, ACADM, ITPKA, IMPDH1, SCD5, FADS2, ACHE, CA4, and HK3 independently predicted prognosis of ccRCC patients. Here, ACHE is linked to nonpapillary renal cell carcinoma.