Multivariate Cox regression analysis showed that 11 of the 12 genes, namely, NOS1, ALAD, ALDH3B2, ACADM, ITPKA, IMPDH1, SCD5, FADS2, ACHE, CA4, and HK3 independently predicted prognosis of ccRCC patients. This evidence concerns the gene NOS1 and nonpapillary renal cell carcinoma.