We used the cBioPortal online tool to analyze the mutation frequencies in the 10 hub genes, namely, GAPDH, POLR3B, NME1-NME2, ADCY10, ADCY7, POLR2F, NME1, ENTPD2, ADCY8, and ADCY3 in ccRCC tissues (TCGA, Firehose Legacy). Here, NME1 is linked to nonpapillary renal cell carcinoma.