This original article of T1D in NOD mice shows that the 10-week-old female NOD mice with T1D after islet transplantation presented with a decreased secretion of IL-1α, IL-1β, CXCL2, MCP1 and TNF-α while an increased secretion of IL-1Rα and IL-10 when compared to the T1D model. This evidence concerns the gene TNF and type 1 diabetes mellitus.