Additionally, the model accurately predicted OS and RFS between the low- and high-risk groups in subclusters including patients of various ages and genders, as well as smoking status, cancer stage, presence of epidermal growth factor receptor (EGFR) mutation, and those with EGFR/KRAS/anaplastic lymphoma kinase (ALK)-negative LUAD (Table 2). The gene discussed is ALK; the disease is cancer.