The current data suggested that two upregulated DEPs (Apoe and Mapk1) and five downregulated DEPs (Ndufv1, Ndufa11, COX2, Gapdh, and Ppp3r1) were involved in Alzheimer's disease signaling in the PSD:ZDF group, while three upregulated DEPs (Lrp1, Ndufb6, and Gapdh) and two downregulated DEPs (Apoe and Mapk1) were observed in the PDZ:PSD group. Here, MAPK1 is linked to early-onset autosomal dominant Alzheimer disease.