MAPK1 and Alzheimer disease: There were seven DEPs (i.e., Apoe, Ndufv1, Ndufa11, COX2, Gapdh, Mapk1, and Ppp3r1) observed in the AD pathway and five DEPs (i.e., Ndufv1, Ndufa11, COX2, Atp5l, and ND2) were observed in the OXPHOS pathway (Figure 8E, 8G).