CRP and major depressive disorder: The current study examines a large community-based sample (n = 880) to investigate (i) associations between serum CRP and DNAm CRP and MDD symptoms, (ii) associations between both CRP (serum CRP and DNAm CRP) measures and structural imaging phenotypes (TI and diffusion MRI) and (iii) interaction effects between both measures of CRP and MDD diagnosis to determine the differential relationship of these inflammatory markers and imaging associations in depression.