A previous study indicated that TAMs could induce the proliferation of endothelial cells and the formation of a vascular network in a vascular endothelial growth factor (VEGF)-dependent manner, and TAMs expressed VEGF-A in the perivascular area at the front of tumor invasion,6 which was confirmed to be helpful to increase MVD and hematogenous metastasis of tumors.7 This evidence concerns the gene VEGFA and neoplasm.