As in males, female Adipo-PRDM16 KO; Mstn-/- and Mstn-/- had comparable body weight (Tukey post-hoc p = 0.10) and were equally protected from obesity compared to Adipo-PRDM16 KO and WT controls (Tukey post-hoc p < 0.001) (Supplementary Figure 6C and Table S3). The gene discussed is MSTN; the disease is obesity due to melanocortin 4 receptor deficiency.