Transcript levels of soluble factors often linked to cancer-promoting (CP) inflammation, such as IL-6, CXCL1, CXCL2, IL-1β, or G-CSF, were markedly higher in COX-competent compared to COX-deficient tumors, and their expression was unchanged in the absence of NK cells (Figure 3D). The gene discussed is IL1B; the disease is cancer.