We focused on cancer types in which we found evidence of divergent inflammatory profiles associated with COX-2 expression levels, such as LUAD, HNSC, TNBC, metastatic skin cutaneous melanoma (MSKCM), cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), kidney renal clear cell carcinoma (KIRC), or ovarian cancer (OV). Here, PTGS2 is linked to ovarian carcinoma.