IFNG and neoplasm: Objective responses from ICB are generally greater in the so-called “hot” T cell-inflamed tumors characterized by higher CTL infiltration, tumor mutational burden (TMB), neoantigen load, and clonality or IFN-γ signaling (Ayers et al., 2017; Cristescu et al., 2018; McGranahan et al., 2016; Rizvi et al., 2015; Snyder et al., 2014; Van Allen et al., 2015).