The ferrireductase DCYTB was apically expressed on choroid plexus epithelial cells, suggesting that they import iron from the CSF via DMT1 and its coupled DCYTB (21); conversely, the expression of the transferrin receptor (TfR1) had a basolateral pattern (22) and was increased in iron deficiency (51). Here, STEAP3 is linked to Iron deficiency anemia.