In addition, the results of Western blot analysis demonstrated that the contents of Vimentin and N‐cadherin in tumour tissues were increased, while that of E‐cadherin was decreased by EVs cultured under either normoxic or hypoxic conditions in contrast to PBS treatment; among the three treatment patterns, hypoxic EVs exerted the most substantial effects in terms of altering the content of EMT markers. Here, CDH2 is linked to neoplasm.