PPARGC1A and major depressive disorder: Given that the PPARγ coactivator PGC1α protects from stress‐induced changes associated with depression through the regulation of kynurenine aminotransferase (Agudelo et al., 2014), it can be envisioned that PPARγ and PGC1α may cooperate in regulating the levels of kynurenine, given the presence of PPREs in the kynurenine aminotransferase gene promoter (Agudelo et al., 2014).