Wang et al16 found that miR‐138‐5p was abnormal in myocardial infarction patients and mice, and miR‐138‐5p promoted H/R‐induced cardiotoxicity and regulated cardiomyocyte apoptosis through the SIRT1‐PGC‐1α pathway, which was similar with the role of miR‐138‐5p was involved in H/R‐induced cardiomyocyte apoptosis in this study. The gene discussed is SIRT1; the disease is myocardial infarction.