Of these 34 mSRGs that were repressed at the epigenomic and transcriptomic level by chronic inflammation in mice, only 7 genes (20%) were confirmed to be human SRGs as they were downregulated by > twofold in human RA FLS treated with TNF for 8 h and 24 h (Fig. 5B and SupplementaryTable S4). This evidence concerns the gene TNF and rheumatoid arthritis.