Moreover, recent reports have revealed that LKB1 activity in HCC might be correlated with diverse types of posttranslational modifications, such as phosphorylation, neddylation, ubiquitination, and acetylation19,20, indicating that detailed analysis of PTMs in the LKB1 protein might be helpful for determining the role of LKB1 in HCC. This evidence concerns the gene STK11 and hepatocellular carcinoma.