HCC patients had significantly increased PTX3 levels [15.6 (9.6–24.3) ng/mL] compared with patients with chronic hepatitis [3.7 (1.6–6.4) ng/mL, P < 0.001, Figure S1B], cirrhosis [6.2 (3–9) ng/mL, P < 0.001, Figure S1B,] or chronic HBV infection without HCC [chronic hepatitis + cirrhosis, 4.2 (2–7.9) ng/mL, P < 0.001, Figure S1C]. This evidence concerns the gene PTX3 and chronic hepatitis.