The corresponding results of combination of PTX3 with AFP were: HCC versus chronic hepatitis: AUC (95%CI) 0.960 (0.929–0.980), sensitivity 89.7%, specificity 87.4% (Fig. 1A); HCC versus cirrhosis: AUC (95%CI) 0.939 (0.898–0.968), sensitivity 79.4%, specificity 99.0% (Fig. 1B); and HCC versus chronic HBV infection without HCC: AUC (95%CI) 0.951 (0.924–0.971), sensitivity 80.4%, specificity 96.1% (Fig. 1C, Table 3). This evidence concerns the gene AFP and Cirrhosis.