The corresponding results of AFP were: HCC versus chronic hepatitis: AUC (95% CI) 0.724 (0.666–0.776), sensitivity 70.1%, specificity 72.3% (Fig. 2A); HCC versus cirrhosis: AUC (95% CI) 0.735 (0.670–0.794), sensitivity 68.2%, specificity 70.7% (Fig. 1B); and HCC versus chronic HBV infection without HCC: AUC (95%CI) 0.728 (0.679–0.773), sensitivity 70.1%, specificity 70.5% (Fig. 1C). The gene discussed is AFP; the disease is hepatocellular carcinoma.