The corresponding results of AFP were: HCC versus chronic hepatitis: AUC (95%CI) 0.625 (0.540–0.704), sensitivity 40.6%, specificity 86.7% (Fig. 2A); HCC versus cirrhosis: AUC (95%CI) 0.531 (0.429–0.632), sensitivity 65.6%, specificity 51.5% (Fig. 2B); and HCC versus chronic HBV infection without HCC: AUC (95%CI) 0.587 (0.518–0.654), sensitivity 65.6%, specificity 57.2% (Fig. 2C, Table S4). This evidence concerns the gene AFP and chronic hepatitis.