In relation to HBV infection without HCC, in addition to gender (OR 14.364, P = 0.003), age (OR 1.100, P < 0.001), HBV DNA (OR 0.672, P = 0.015) and AFP (OR 1.001, P = 0.002), PTX3 (OR 1.617, P < 0.001) was also an independent risk factor for HCC (Table 2). Here, PTX3 is linked to hepatocellular carcinoma.