Multivariate logistic regression on factors for HCC showed that, in comparison with chronic hepatitis, in addition to gender (OR 19.288, P = 0.003), age (OR 1.137, P < 0.001) and AFP (OR 1.001, P = 0.014), PTX3 (OR 1.639, P < 0.001) was an independent risk factor for HCC (Table 2). The gene discussed is PTX3; the disease is chronic hepatitis.