In relation to cirrhosis, together with gender (OR 5.612, P = 0.041), age (OR 1.061, P = 0.047), HBV DNA (OR 0.619, P = 0.022) and albumin (OR 0.909, P = 0.026), PTX3 (OR 1.671, P < 0.001) was an independent risk factor for HCC (Table 2). The gene discussed is ALB; the disease is hepatocellular carcinoma.