KLF4 and acute myeloid leukemia: To further demonstrate the importance of DPYSL2A in KLF4-mediated monocytic differentiation in AML cells, we designed doxycycline-inducible shRNAs specifically targeting DPYSL2A (sh_DPYSL2A #1 and #2) and lentivirally transduced them into THP-1 and KO52 cells.