ATG7 and breast cancer: Given the finding that ATG7 levels were similar in the cells generated from BCs and LPs cultured under similar conditions, but at non-limiting cell concentrations (Fig. 2E), and the specific requirement of ATG7 for autophagic function via its role in converting LC3-I to LC3-II30,31, we also compared the effect of specifically inhibiting the expression of ATG7 on BC and LP clonogenic activity.