FAM3D and pouchitis: Peptostreptococcus, more abundant in Fam3D−/− mice, is also significantly enriched in patients with UC and CRC41. In addition, Clostridium perfringens exerts proteolytic and mucinase activity, both of which may play a role in the pathogenesis of pouchitis, a colon inflammatory disease42 and may be attributed in part to a thinner mucus layer observed in the colon of Fam3D−/− mice.