Although precise mechanisms for the cooperative binding of these dimers are unknown, considering previous reports describing that CEBPB serves as a pioneer factor for enhancer establishment in cancer cells as well as in normal hematopoietic stem cells45,46, CEBPB may contribute to create a permissive chromatin environment for NRF2-small Maf heterodimer to access regulatory regions of unique target genes in NRF2-activated NSCLC cells. This evidence concerns the gene NFE2L2 and cancer.