Of 36 NRF2-activated NSCLC-specific NRF2 downstream effector genes (see Fig. 1f and Supplementary Fig. 2a), 21 genes, including NOTCH3, were regarded as direct NRF2 target genes based on the presence of NRF2 binding accompanied by the NRF2-dependent H3K27ac deposition (Fig. 5a and Supplementary Fig. 8e). This evidence concerns the gene NOTCH3 and non-small cell lung carcinoma.