To evaluate whether PDK2 is involved in diabetes-induced hypothalamic inflammatory processes and subsequent metabolic and behavioral dysfunction, we first performed immunofluorescence analyses that showed increased immunoreactivity for GFAP (Fig. 2a) and Iba-1 (Fig. 2b) in the hypothalamus at 3 weeks after STZ injection. The gene discussed is GFAP; the disease is diabetes mellitus.