Remarkably, overexpression of hypothalamic PDK2 reversed the effects of Pdk2 KO on diabetes-induced Tnf-α, Il-1β, and Il-6 mRNA expression (Fig. 6c), food intake (Fig. 6d), blood glucose (Fig. 6e), and expression of Npy, Agrp, and Pomc in the diabetic hypothalamus at 3 weeks post-STZ injection (Fig. 6f). Here, PDK2 is linked to diabetes mellitus.