In addition, mice with selective deletion of Pdk2 in hypothalamic astrocytes showed lower levels of diabetes-induced food intake (Fig. 8e), lactate surge (Fig. 8d), and Npy and Agrp mRNAs but higher levels of Pomc mRNA (Fig. 8f) in the hypothalamus when compared with the AAV5-GFAP-eYFP-injected diabetic animals. This evidence concerns the gene AGRP and diabetes mellitus.