This is also seen in animal models of AD, where zinc is elevated in plaques of APP/PS1 mice determined by Timm’s stain (58) as well as X-ray fluorescence microscopy (59), plaques of Tg2576 mice determined by metallomic imaging mass spectrometry (60), and plaques within the amygdala of aged (over 23-years-old) macaques (61). The gene discussed is APP; the disease is Alzheimer disease.