APP and Alzheimer disease: Moreover, wild-type rats, Tg2576 mice, or 3xTg-AD mice with copper-enriched drinking water have been reported to exaggerate cognitive impairment and to worsen neurodegeneration (204, 205, 206, 207), in contrast to one report of dietary copper supplementation suppressing amyloid pathology in transgenic APP23 mice, carrying the Swedish APP mutation (138).