PNPLA2 and neoplasm: Indeed, tumor progression is accelerated by reduced activity of adipose triglyceride lipase (ATGL, formally PNPLA2), the rate-limiting TG lipase, or loss of αβ hydrolase domain containing 5 (ABHD5), the essential coactivator of ATGL (11, 12, 13, 14, 15, 16, 17).