In addition, structure–function studies suggest that the spike protein of SARS-CoV-2 is highly glycosylated [40] and it has been hypothesized that high concentration of glycosylated SARS-CoV-2 viral particles and glycosylated ACE2 in the lung epithelium, due to hyperglycemia, may influence the susceptibility to COVID-19 infection and its subsequent severity [41]. Here, ACE2 is linked to Hyperglycemia.