A number of strategies have been suggested to reduce the incidence of OHSS, such as coasting [14], GnRH-ant protocol with GnRH-a for trigger [15, 16], HES [17, 18], human albumin [19], aspirin [20, 21], dopamine agonist [22], calcium [23], metformin [24], aspiration of pleural effusion [25]. Here, GNRH1 is linked to Pleural effusion.