TF and acute lymphoblastic leukemia: In further confirmation, we analyzed TF expression matching the positive TF regulons with high activity in E/R+ cells (top panel, Fig. 5a) across large bulk gene expression datasets [67, 89] (Hemap, N = 9544, with 1304 pre-B-ALL samples; Pan-ALL, with 1988 pre-B-ALL samples; see also Additional file 1, Fig. S5 and RNA-seq PanALL data in Additional file 5, Table S4).