The previous meta-analyses [18–21] examined PON1 only but our study included PON2 (rs7493) on account of its full LD with rs705379 and rs854572 of PON1. To our knowledge, this is the fifth meta-analysis to address the PON-PCOS associations, but the first to accomplish the following: (i) perform an umbrella review (Table S3); (ii) apply outlier treatment with the most number (n = 12) of included articles; and (iii) operate within LD parameters. Here, PON1 is linked to polycystic ovary syndrome.