In a recent study by Wang et al., the importance of the immune status of NPC was underscored: focusing on immune checkpoints PD-L1 and B7-H4 on tumor cells and PD-L1, B7-H3, B7-H4, IDO-1, VISTA, ICOS, and OX40 on intralesional immune cells, specific signatures were demonstrated to predict survival [1]. The gene discussed is VTCN1; the disease is neoplasm.