Concerning PARPs, PARP1 is a nuclear protein which contributes in DNA single-strand break repair, and its dysregulation is involved in tumorigenesis phenomena to such a degree that PARP1 inhibitors have been authorized for the treatment of some types of BC, stimulating both apoptosis induction and synthetic lethality mechanism/DNA repair [23,24,25,26,27]. Here, PARP1 is linked to breast cancer.