Similarly, F. nucleatum may be also associated with promoted gene expression in HNSCC, including SULF1, TREM2, MMP2, KRTAP5-10, SCN5A, JAKMIP1, KRTAP5-9, ECE2, LILRA6, KCNAB2, ERC2, KIF26A, USP31, PLCG2, and SLC22A25 (log2FC ≥ 0.5, adjusted p ≤ 0.01), given the observed hypomethylation of gene promoters related to the enrichment of F. nucleatum. The gene discussed is ECE2; the disease is head and neck squamous cell carcinoma.