Both genes were overexpressed in human cancers, such as gastric, lung, or colorectal cancer [50,51], and were reported to remodel or breakdown extracellular matrix (ECM) [44], resulting in dysregulated cell signaling pathways (e.g., Wnt signaling pathway) [41], or release of growth factors such as TGF-β [45] that affect cell immune tolerance, adhesion, proliferation, and migration [52]. This evidence concerns the gene TGFB1 and colorectal cancer.