Tumor suppressor gene (TSG) latexin (LXN) expression negatively correlates with the prognosis of several human cancers and plays significant roles in inflammatory response, tumor cell migration, invasion and apoptosis (Figure 5B); and TSG-SMARCA2 is involved in ATP-dependent chromatin remodeling related to DNA repair and replication (Figure 5C), implying a potential role of F. nucleatum infection in gene dysregulation related to the inflammatory response and cell proliferation through epigenetic silencing. Here, LXN is linked to cancer.