The tumor suppressor gene (TSG) latexin (LXN) has been downregulated in a number of human cancers, including lymphoma, gastric carcinoma, and thyroid carcinoma [37,38,39], and the TCGA HNSCC cohort, in congruence with its promoter hypermethylation in Fusobcaterium-high tumor tissues. The gene discussed is LXN; the disease is head and neck squamous cell carcinoma.