RHOA and neoplasm: The studies using these engineered mice have shown that Δ122p53 promotes tumor invasion and metastasis by regulating secretion of pro-inflammatory IL-6 and CCL2 [68] and that Δ122p53-induced IL-6 secretion activates JAK-STAT3 and RhoA-ROCK signaling leading to higher tumor incidence and metastasis [41].