For example, Lei and colleagues [123] described the increased proliferation of Pax6+ RGCs in VZ and reduced NPCs exiting the cell cycle in a conditional knockout mouse for Kdm6a (Lysine Demethylase 6A, also known as Utx), a lysine demethylase implicated in ID (Kabuki syndrome, OMIM 300867) affecting Pten transcription. This evidence concerns the gene KDM6A and Kabuki syndrome.