IL33 and chronic rhinosinusitis with nasal polyps: CRSwNP is associated with a high rate of nasal colonization by Staphylococcus aureus (S. aureus), which is associated with a severe disease phenotype, and S. aureus superantigens have been implicated in the pathogenesis of the Th2 response in the nasal mucosa as they induce the release of several cytokines such as IL-33 [36,48,49,50].